Cpt1a ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCpt1a ELISA Kit for Rat(Rattus norvegicus)

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Cpt1a (Gene name),

Carnitine O-palmitoyltransferase 1, liver isoform (Protein name ), CPT1A_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cpt1a(Cpt-1;Cpt1);

Protein name:

Carnitine O-palmitoyltransferase 1, liver isoform(CPT1-L);

Alternative:

Carnitine palmitoyltransferase 1A;Carnitine O-palmitoyltransferase I, liver isoform(CPT I;CPTI-L);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

N/A

Function:

N/A

Subcellular Location:

Mitochondrion outer membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

773

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

773:

GKHLRQAMMD | IITLFGLTIN | SKK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:25757

Pfam:

PF00755

String:

P32198

UniGene:

Rn.2856

Uniprot:

P32198

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ELISA Kit for Rat CPT1-L

Cat.:

E0375r

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96T

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ELISA Kit for Rat CPT1-L

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E0375h

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96T

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ELISA Kit for Rat CPT1-L

Cat.:

E0375m

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96T

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CLIA Kit for Rat CPT1-L

Cat.:

U0375r

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96T

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CLIA Kit for Rat CPT1-L

Cat.:

U0375h

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96T

CLIA Kit for Rat CPT1-L

Cat.:

U0375m

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96T

Polyclonal Antibody for Rat CPT1-L

Cat.:

P0375Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat CPT1-L

Cat.:

P0375Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat CPT1-L

Cat.:

P0375Rb-h

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40ug/0.2ml

Monoclonal Antibody for Rat CPT1-L

Protein for Rat CPT1-L

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function."
Esser V. , Britton C.H. , Weis B.C. , Foster D.W. , McGarry J.D.
J. Biol. Chem.268:5817-5822(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris."
de Vries Y. , Arvidson D.N. , Waterham H.R. , Cregg J.M. , Woldegiorgis G.
Biochemistry36:5285-5292(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Liver.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Heart.
4.

"Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry."
Distler A.M. , Kerner J. , Hoppel C.L.
Biochim. Biophys. Acta1774:628-636(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-22; 272-283; 585-595 AND 599-606;ACETYLATION AT ALA-2;NITRATION AT TYR-282 AND TYR-589;PHOSPHORYLATION AT THR-588; THR-604; SER-741 AND SER-747;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Liver.
5.

"Mature carnitine palmitoyltransferase I retains the N-terminus of the nascent protein in rat liver."
Kolodziej M.P. , Zammit V.A.
FEBS Lett.327:294-296(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 4-21; 259-276; 361-379; 529-543 AND 696-717
tissue: Liver.
6.

"Inhibitors of mitochondrial carnitine palmitoyltransferase I limit the action of proteases on the enzyme. Isolation and partial amino acid analysis of a truncated form of the rat liver isozyme."
Esser V. , Kuwajima M. , Britton C.H. , Krishnan K. , Foster D.W. , McGarry J.D.
J. Biol. Chem.268:5810-5816(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
7.

"Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipocytes."
Esser V. , Brown N.F. , Cowan A.T. , Foster D.W. , McGarry J.D.
J. Biol. Chem.271:6972-6977(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
strain: Sprague-Dawley.
tissue: Heart.
8.

"Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane."
Fraser F. , Corstorphine C.G. , Zammit V.A.
Biochem. J.323:711-718(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
9.

"Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity."
Morillas M. , Gomez-Puertas P. , Roca R. , Serra D. , Asins G. , Valencia A. , Hegardt F.G.
J. Biol. Chem.276:45001-45008(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ALA-381 AND HIS-473;3D-STRUCTURE MODELING
10.

"Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition."
Morillas M. , Gomez-Puertas P. , Bentebibel A. , Selles E. , Casals N. , Valencia A. , Hegardt F.G. , Asins G. , Serra D.
J. Biol. Chem.278:9058-9063(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF MET-593 AND CYS-608
11.

"Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal."
Morillas M. , Lopez-Vinas E. , Valencia A. , Serra D. , Gomez-Puertas P. , Hegardt F.G. , Asins G.
Biochem. J.379:777-784(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-477; LYS-560; GLU-590; SER-685; THR-686 AND SER-687;3D-STRUCTURE MODELING
12.

"The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity."
Borthwick K. , Jackson V.N. , Price N.T. , Zammit V.A.
J. Biol. Chem.281:32946-32952(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;ENZYME REGULATION
13.

"A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels."
Stefanovic-Racic M. , Perdomo G. , Mantell B.S. , Sipula I.J. , Brown N.F. , O'Doherty R.M.
Am. J. Physiol.294:E969-E977(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs."
Jenei Z.A. , Borthwick K. , Zammit V.A. , Dixon A.M.
J. Biol. Chem.284:6988-6997(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
15.

"Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex."
Lee K. , Kerner J. , Hoppel C.L.
J. Biol. Chem.286:25655-25662(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;IDENTIFICATION IN A COMPLEX WITH ACSL1 AND VDAC1; IDENTIFICATION IN COMPLEXES WITH ACSL1; VDAC2 AND VDAC3;IDENTIFICATION BY MASS SPECTROMETRY
16.

"An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A."
Rao J.N. , Warren G.Z. , Estolt-Povedano S. , Zammit V.A. , Ulmer T.S.
J. Biol. Chem.286:42545-42554(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;ENZYME REGULATION;DOMAIN;MUTAGENESIS OF GLU-3; ALA-9 AND GLY-18

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